Cargando…

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis. The parasite clearance profile after drug treatment in preclinical st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parkyn Schneider, Molly, Looker, Oliver, Rebelo, Maria, Khoury, David S., Dixon, Matthew W. A., Oeuvray, Claude, Crabb, Brendan S., McCarthy, James, Gilson, Paul R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340534/ https://www.ncbi.nlm.nih.gov/pubmed/37457953 http://dx.doi.org/10.3389/fcimb.2023.1211613

Ejemplares similares

Evaluation of a multiphasic parasite clearance profile after treatment of experimental human infection with the investigational anti-malarial M5717 using segmented mixed effect models
por: Yin, Xiaoyan, et al.
Publicado: (2023)

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor
por: Rottmann, Matthias, et al.
Publicado: (2020)

Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
por: Khandelwal, Akash, et al.
Publicado: (2022)

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum
por: Jonsdottir, Thorey K., et al.
Publicado: (2023)

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
por: Looker, Oliver, et al.
Publicado: (2022)

Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical Plasmodium Infection Models
por: Fontinha, Diana, et al.
Publicado: (2022)

Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study
por: McCarthy, James S, et al.
Publicado: (2021)

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture
por: Bullen, Hayley E., et al.
Publicado: (2022)

Plasmodium falciparum virulence determinants unveiled
por: Crabb, Brendan S, et al.
Publicado: (2002)

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export
por: Charnaud, Sarah C., et al.
Publicado: (2018)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites
por: Weiss, Greta E., et al.
Publicado: (2023)

Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia
por: Watts, Rebecca E., et al.
Publicado: (2020)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
por: Dickerman, Benjamin K., et al.
Publicado: (2016)

Development of fluorescent Plasmodium falciparum for in vitro growth inhibition assays
por: Wilson, Danny W, et al.
Publicado: (2010)

Molecular incidence and clearance of Plasmodium falciparum infection
por: Krogstad, Donald J., et al.
Publicado: (2015)

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
por: Parkyn Schneider, Molly, et al.
Publicado: (2017)

Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection
por: Farid, Ryan, et al.
Publicado: (2017)

Plasmodium falciparum Transfected with Ultra Bright NanoLuc Luciferase Offers High Sensitivity Detection for the Screening of Growth and Cellular Trafficking Inhibitors
por: Azevedo, Mauro F., et al.
Publicado: (2014)

Inability to Reverse Aspirin and Clopidogrel-induced Platelet Dysfunction with Platelet Infusion
por: Cohn, Stephen M, et al.
Publicado: (2019)

Inability and Obligation in Moral Judgment
por: Buckwalter, Wesley, et al.
Publicado: (2015)

Inability to Culture Pneumocystis jirovecii
por: Liu, Yueqin, et al.
Publicado: (2018)

Syncope and the Inability to Move: Was It the Magnesium?
por: Perkins, David R, et al.
Publicado: (2023)

Systematic Analysis of FKBP Inducible Degradation Domain Tagging Strategies for the Human Malaria Parasite Plasmodium falciparum
por: de Azevedo, Mauro Ferreira, et al.
Publicado: (2012)

Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia
por: Pasay, Cielo J., et al.
Publicado: (2016)

Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages
por: Bouharoun-Tayoun, Hasnaa, et al.
Publicado: (2015)

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites
por: Yap, Alan, et al.
Publicado: (2014)

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
por: Dans, Madeline G., et al.
Publicado: (2023)

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes
por: Tham, Wai-Hong, et al.
Publicado: (2015)

Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage
por: Tibúrcio, Marta, et al.
Publicado: (2015)

A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite’s PI4KIIIB Enzyme
por: Ling, Dawson B., et al.
Publicado: (2023)

Sex-based differences in clearance of chronic Plasmodium falciparum infection
por: Briggs, Jessica, et al.
Publicado: (2020)

Pelvic Abscess with Presentation as Inability to Ambulate
por: Damer, Sarah A.
Publicado: (2017)

Infant with inability to abduct left eye
por: Dodderer, Joshua K., et al.
Publicado: (2021)

Classification of invasive bloodstream infections and Plasmodium falciparum malaria using autoantibodies as biomarkers
por: Krumkamp, Ralf, et al.
Publicado: (2020)

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes
por: Riglar, David T., et al.
Publicado: (2013)

The Rapid and Spontaneous Postpartum Clearance of Plasmodium falciparum Is Related to Expulsion of the Placenta
por: Anabire, Nsoh G, et al.
Publicado: (2023)

The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites
por: Charnaud, Sarah C., et al.
Publicado: (2017)

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator
por: Flegg, Jennifer A, et al.
Publicado: (2011)

Human Malaria in Immunocompromised Mice: An in Vivo Model to Study Defense Mechanisms against Plasmodium falciparum
por: Badell, Edgar, et al.
Publicado: (2000)

Immunity over inability: The spontaneous regression of cancer
por: Jessy, Thomas
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lgh77mmptknd1lb824tq3859nh