Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport

SIMPLE SUMMARY: P-glycoprotein (P-gp, ABCB1) is an ATP-binding cassette (ABC) transporter that contributes to the development of multidrug resistance (MDR) in cancer cells. P-gp pumps various amphipathic agents including anticancer drugs out of cells. The elucidation of the P-gp mechanism of drug tr...

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Detalles Bibliográficos
Autores principales: Rahman, Hadiar, Ware, Mark J., Sajid, Andaleeb, Lusvarghi, Sabrina, Durell, Stewart R., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340712/
https://www.ncbi.nlm.nih.gov/pubmed/37444569
http://dx.doi.org/10.3390/cancers15133459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340712/
https://www.ncbi.nlm.nih.gov/pubmed/37444569
http://dx.doi.org/10.3390/cancers15133459

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