3K3A-Activated Protein C Inhibits Choroidal Neovascularization Growth and Leakage and Reduces NLRP3 Inflammasome, IL-1β, and Inflammatory Cell Accumulation in the Retina

3K3A-Activated Protein C (APC) is a recombinant variant of the physiological anticoagulant APC with cytoprotective properties and reduced bleeding risks. We studied the potential use of 3K3A-APC as a multi-target therapeutic option for choroidal neovascularization (CNV), a common cause of vision los...

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Detalles Bibliográficos
Autores principales: Weinberger, Yehonatan, Budnik, Ivan, Nisgav, Yael, Palevski, Dahlia, Ben-David, Gil, Fernández, José A., Margalit, Shany Nivinsky, Levy-Mendelovich, Sarina, Kenet, Gili, Weinberger, Dov, Griffin, John H., Livnat, Tami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341424/
https://www.ncbi.nlm.nih.gov/pubmed/37445820
http://dx.doi.org/10.3390/ijms241310642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341424/
https://www.ncbi.nlm.nih.gov/pubmed/37445820
http://dx.doi.org/10.3390/ijms241310642

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