LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis

Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in idiopathic and familial Parkinson’s disease (PD). However, how exactly this kinase participates in the OS-mitochondria-apoptosis...

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Detalles Bibliográficos
Autores principales: Quintero-Espinosa, Diana Alejandra, Sanchez-Hernandez, Sabina, Velez-Pardo, Carlos, Martin, Francisco, Jimenez-Del-Rio, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341561/
https://www.ncbi.nlm.nih.gov/pubmed/37445652
http://dx.doi.org/10.3390/ijms241310474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341561/
https://www.ncbi.nlm.nih.gov/pubmed/37445652
http://dx.doi.org/10.3390/ijms241310474

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