Extensive Bioinformatics Analyses Reveal a Phylogenetically Conserved Winged Helix (WH) Domain (Zτ) of Topoisomerase IIα, Elucidating Its Very High Affinity for Left-Handed Z-DNA and Suggesting Novel Putative Functions

The dynamic processes operating on genomic DNA, such as gene expression and cellular division, lead inexorably to topological challenges in the form of entanglements, catenanes, knots, “bubbles”, R-loops, and other outcomes of supercoiling and helical disruption. The resolution of toxic topological...

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Detalles Bibliográficos
Autores principales: Bartas, Martin, Slychko, Kristyna, Červeň, Jiří, Pečinka, Petr, Arndt-Jovin, Donna J., Jovin, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341724/
https://www.ncbi.nlm.nih.gov/pubmed/37445918
http://dx.doi.org/10.3390/ijms241310740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341724/
https://www.ncbi.nlm.nih.gov/pubmed/37445918
http://dx.doi.org/10.3390/ijms241310740

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