Intra-Articular Lactate Dehydrogenase A Inhibitor Oxamate Reduces Experimental Osteoarthritis and Nociception in Rats via Possible Alteration of Glycolysis-Related Protein Expression in Cartilage Tissue

Osteoarthritis (OA) is the most common form of arthritis and joint disorder worldwide. Metabolic reprogramming of osteoarthritic chondrocytes from oxidative phosphorylation to glycolysis results in the accumulation of lactate from glycolytic metabolite pyruvate by lactate dehydrogenase A (LDHA), lea...

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Detalles Bibliográficos
Autores principales: Wen, Zhi-Hong, Sung, Chun-Sung, Lin, Sung-Chun, Yao, Zhi-Kang, Lai, Yu-Cheng, Liu, Yu-Wei, Wu, Yu-Yan, Sun, Hsi-Wen, Liu, Hsin-Tzu, Chen, Wu-Fu, Jean, Yen-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341729/
https://www.ncbi.nlm.nih.gov/pubmed/37445948
http://dx.doi.org/10.3390/ijms241310770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341729/
https://www.ncbi.nlm.nih.gov/pubmed/37445948
http://dx.doi.org/10.3390/ijms241310770

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