Recombinant Human CD19 in CHO-K1 Cells: Glycosylation Patterns as a Quality Attribute of High Yield Processes

CD19 is an essential protein in personalized CD19-targeting chimeric antigen receptor (CAR)-T cell-based cancer immunotherapies and CAR-T cell functionality evaluation. However, the recombinant expression of this “difficult to-express” (DTE) protein is challenging, and therefore, commercial access t...

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Detalles Bibliográficos
Autores principales: Billerhart, Magdalena, Hunjadi, Monika, Hawlin, Vanessa, Grünwald-Gruber, Clemens, Maresch, Daniel, Mayrhofer, Patrick, Kunert, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341778/
https://www.ncbi.nlm.nih.gov/pubmed/37446069
http://dx.doi.org/10.3390/ijms241310891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341778/
https://www.ncbi.nlm.nih.gov/pubmed/37446069
http://dx.doi.org/10.3390/ijms241310891

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