Antisera Produced Using an E. coli-Expressed SARS-CoV-2 RBD and Complemented with a Minimal Dose of Mammalian-Cell-Expressed S1 Subunit of the Spike Protein Exhibits Improved Neutralization

E. coli-expressed proteins could provide a rapid, cost-effective, and safe antigen for subunit vaccines, provided we can produce them in a properly folded form inducing neutralizing antibodies. Here, we use an E. coli-expressed SARS-CoV-2 receptor-binding domain (RBD) of the spike protein as a model...

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Detalles Bibliográficos
Autores principales: Yoshizue, Takahiro, Brindha, Subbaian, Wongnak, Rawiwan, Takemae, Hitoshi, Oba, Mami, Mizutani, Tetsuya, Kuroda, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341788/
https://www.ncbi.nlm.nih.gov/pubmed/37445760
http://dx.doi.org/10.3390/ijms241310583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341788/
https://www.ncbi.nlm.nih.gov/pubmed/37445760
http://dx.doi.org/10.3390/ijms241310583

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