Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis

The enhancement of the endocannabinoid tone might have a beneficial influence on hypertension. Polypharmacology proposes multi-target-directed ligands (MTDLs) as potential therapeutic agents for the treatment of complex diseases. In the present paper, we studied JZL195, a dual inhibitor of the two m...

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Detalles Bibliográficos
Autores principales: Toczek, Marek, Ryszkiewicz, Piotr, Remiszewski, Patryk, Schlicker, Eberhard, Krzyżewska, Anna, Kozłowska, Hanna, Malinowska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341834/
https://www.ncbi.nlm.nih.gov/pubmed/37446125
http://dx.doi.org/10.3390/ijms241310942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341834/
https://www.ncbi.nlm.nih.gov/pubmed/37446125
http://dx.doi.org/10.3390/ijms241310942

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