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Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
The enhancement of the endocannabinoid tone might have a beneficial influence on hypertension. Polypharmacology proposes multi-target-directed ligands (MTDLs) as potential therapeutic agents for the treatment of complex diseases. In the present paper, we studied JZL195, a dual inhibitor of the two m...
Autores principales: | Toczek, Marek, Ryszkiewicz, Piotr, Remiszewski, Patryk, Schlicker, Eberhard, Krzyżewska, Anna, Kozłowska, Hanna, Malinowska, Barbara |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341834/ https://www.ncbi.nlm.nih.gov/pubmed/37446125 http://dx.doi.org/10.3390/ijms241310942 |
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