Mitochondria-Targeting 1,5-Diazacyclooctane-Spacered Triterpene Rhodamine Conjugates Exhibit Cytotoxicity at Sub-Nanomolar Concentration against Breast Cancer Cells

1,5-Diazacyclooctane was prepared by a simple synthetic sequence and coupled to pentacyclic triterpenoic acids oleanolic acid, ursolic acid, betulinic acid, platanic acid, and asiatic acid; these amides were activated with oxalyl chloride and reacted with rhodamine B or rhodamine 101 to yield conjug...

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Detalles Bibliográficos
Autores principales: Heise, Niels, Becker, Selina, Mueller, Thomas, Bache, Matthias, Csuk, René, Güttler, Antje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341912/
https://www.ncbi.nlm.nih.gov/pubmed/37445874
http://dx.doi.org/10.3390/ijms241310695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341912/
https://www.ncbi.nlm.nih.gov/pubmed/37445874
http://dx.doi.org/10.3390/ijms241310695

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