Activation/Inhibition of Cholinesterases by Excess Substrate: Interpretation of the Phenomenological b Factor in Steady-State Rate Equation

Cholinesterases (ChEs) display a non-michaelian behavior with positively charged substrates. In the steady-state rate equation, the b factor describes this behavior: if b > 1 there is substrate activation, if b < 1 there is substrate inhibition. The mechanistic significance of the b factor was...

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Detalles Bibliográficos
Autores principales: Mukhametgalieva, Aliya R., Nemtarev, Andrey V., Sykaev, Viktor V., Pashirova, Tatiana N., Masson, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341919/
https://www.ncbi.nlm.nih.gov/pubmed/37445649
http://dx.doi.org/10.3390/ijms241310472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341919/
https://www.ncbi.nlm.nih.gov/pubmed/37445649
http://dx.doi.org/10.3390/ijms241310472

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