Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells

Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra and the intraneuronal presence of Lewy bodies (LBs), composed of aggregates of phosphorylated alpha-synuclein at residue Ser(129) (p-Ser(129)α-Syn). Unfor...

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Detalles Bibliográficos
Autores principales: Perez-Abshana, Laura Patricia, Mendivil-Perez, Miguel, Velez-Pardo, Carlos, Jimenez-Del-Rio, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341970/
https://www.ncbi.nlm.nih.gov/pubmed/37445771
http://dx.doi.org/10.3390/ijms241310589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341970/
https://www.ncbi.nlm.nih.gov/pubmed/37445771
http://dx.doi.org/10.3390/ijms241310589

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