Cargando…

Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells

Parkinson’s disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra and the intraneuronal presence of Lewy bodies (LBs), composed of aggregates of phosphorylated alpha-synuclein at residue Ser(129) (p-Ser(129)α-Syn). Unfor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perez-Abshana, Laura Patricia, Mendivil-Perez, Miguel, Velez-Pardo, Carlos, Jimenez-Del-Rio, Marlene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10341970/ https://www.ncbi.nlm.nih.gov/pubmed/37445771 http://dx.doi.org/10.3390/ijms241310589

Ejemplares similares

LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis
por: Quintero-Espinosa, Diana Alejandra, et al.
Publicado: (2023)

Response to Rotenone Is Glucose-Sensitive in a Model of Human Acute Lymphoblastic Leukemia: Involvement of Oxidative Stress Mechanism, DJ-1, Parkin, and PINK-1 Proteins
por: Mendivil-Perez, Miguel, et al.
Publicado: (2014)

LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
por: Ysselstein, Daniel, et al.
Publicado: (2019)

Glucocerebrosidase: Functions in and Beyond the Lysosome
por: Boer, Daphne E.C., et al.
Publicado: (2020)

Tubeimoside I induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function
por: Feng, Xuping, et al.
Publicado: (2018)

Disruption of mitochondrial and lysosomal functions by human CACNA1C variants expressed in HEK 293 and CHO cells
por: Kessi, Miriam, et al.
Publicado: (2023)

Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity
por: Ysselstein, Daniel, et al.
Publicado: (2021)

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
por: Klein, Andrés D., et al.
Publicado: (2023)

Thapsigargin blocks electromagnetic field‐elicited intracellular Ca(2+) increase in HEK 293 cells
por: Bertagna, Federico, et al.
Publicado: (2022)

Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines
por: Stillemans, Gabriel, et al.
Publicado: (2021)

TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia and Ex Vivo Acute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways
por: Mendivil-Perez, Miguel, et al.
Publicado: (2012)

Polycationic peptide R(7)-G-Aβ(25-35) selectively induces cell death in leukemia Jurkat T cells through speedy mitochondrial depolarization, and CASPASE-3 -independent mechanism
por: Mendivil-Perez, Miguel, et al.
Publicado: (2022)

TPEN/TPGS (T2) combo dramatically reduces Philadelphia chromosome-positive pro-lymphoblastic B leukemia in BALB/c mice
por: Mendivil-Perez, Miguel, et al.
Publicado: (2022)

Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca(2+) dysregulation: Therapeutic implications
por: Soto-Mercado, Viviana, et al.
Publicado: (2020)

The opioid tramadol blocks the cardiac sodium channel Na(v)1.5 in HEK293 cells
por: Jia, Lixia, et al.
Publicado: (2023)

HEK293S Cells Have Functional Retinoid Processing Machinery
por: Brueggemann, Lioubov I., et al.
Publicado: (2002)

Effects of endotoxin on pacemaker funny current in HEK 293 cells
por: Papaioannou, VP, et al.
Publicado: (2011)

Echinacea-induced cytosolic Ca(2+ )elevation in HEK293
por: Wu, Lankun, et al.
Publicado: (2010)

Effect of PTTG on endogenous gene expression in HEK 293 cells
por: Panguluri, Siva K, et al.
Publicado: (2009)

Analysis of DNA topology of EBV minichromosomes in HEK 293 cells
por: Castán, Alicia, et al.
Publicado: (2017)

HEK293T cell lines defective for O-linked glycosylation
por: Termini, James M., et al.
Publicado: (2017)

Microtubule Integrity Is Associated with the Functional Activity of Mitochondria in HEK293
por: Cho, Min Jeong, et al.
Publicado: (2021)

Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation
por: Yan, Jianghong, et al.
Publicado: (2019)

CD133 induces tumour-initiating properties in HEK293 cells
por: Canis, Martin, et al.
Publicado: (2012)

Differences in the production of hyperglycosylated IFN alpha in CHO and HEK 293 cells
por: Gugliotta, Agustina, et al.
Publicado: (2013)

Cytotoxicity and genotoxicity caused by yttrium oxide nanoparticles in HEK293 cells
por: Selvaraj, Vellaisamy, et al.
Publicado: (2014)

Enhancing Protein Expression in HEK-293 Cells by Lowering Culture Temperature
por: Lin, Chi-Yen, et al.
Publicado: (2015)

Cellular signaling pathways modulated by influenza infection in HEK293 cells
por: Manceur, Aziza P, et al.
Publicado: (2015)

HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation
por: Qi, Chunxia, et al.
Publicado: (2016)

Distinct mechanical behavior of HEK293 cells in adherent and suspended states
por: Haghparast, Seyed Mohammad Ali, et al.
Publicado: (2015)

Using HEK293T Expression System to Study Photoactive Plant Cryptochromes
por: Yang, Liang, et al.
Publicado: (2016)

Lack of current observed in HEK293 cells expressing NALCN channels
por: Egan, Jennifer M., et al.
Publicado: (2018)

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells
por: Blessing, Daniel, et al.
Publicado: (2018)

Degradation of Extracellular NAD(+) Intermediates in Cultures of Human HEK293 Cells
por: Kulikova, Veronika, et al.
Publicado: (2019)

Optimization of Experimental Variables Influencing Apoptosome Biosensor in HEK293T Cells
por: Oladzad, Azarakhsh, et al.
Publicado: (2020)

Characterization of bovine interleukin-2 stably expressed in HEK-293 cells
por: MITOMA, Shuya, et al.
Publicado: (2020)

High Yield of Functional Dopamine-like Neurons Obtained in NeuroForsk 2.0 Medium to Study Acute and Chronic Rotenone Effects on Oxidative Stress, Autophagy, and Apoptosis
por: Quintero-Espinosa, Diana Alejandra, et al.
Publicado: (2023)

Drug resistance-related sunitinib sequestration in autophagolysosomes of endothelial cells
por: Wu, Shuang, et al.
Publicado: (2019)

Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer’s Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB(1) Receptor
por: Soto-Mercado, Viviana, et al.
Publicado: (2021)

(−)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer’s Disease PSEN1 E280A
por: Soto-Mercado, Viviana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vhjl6fjk37pgbpvolqsdclgm64