The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats

Mechanical unloading during microgravity causes skeletal muscle atrophy and impairs mitochondrial energetics. The elevated production of reactive oxygen species (ROS) by mitochondria and Nox2, coupled with impairment of stress protection (e.g., SIRT1, antioxidant enzymes), contribute to atrophy. We...

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Detalles Bibliográficos
Autores principales: Wesolowski, Lauren T., Simons, Jessica L., Semanchik, Pier L., Othman, Mariam A., Kim, Joo-Hyun, Lawler, John M., Kamal, Khaled Y., White-Springer, Sarah H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342025/
https://www.ncbi.nlm.nih.gov/pubmed/37446313
http://dx.doi.org/10.3390/ijms241311135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342025/
https://www.ncbi.nlm.nih.gov/pubmed/37446313
http://dx.doi.org/10.3390/ijms241311135

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