The Pro-Oncogenic Sphingolipid-Metabolizing Enzyme β-Galactosylceramidase Modulates the Proteomic Landscape in BRAF(V600E)-Mutated Human Melanoma Cells

β-Galactosylceramidase (GALC) is a lysosomal enzyme involved in sphingolipid metabolism by removing β-galactosyl moieties from β-galactosylceramide and β-galactosylsphingosine. Previous observations have shown that GALC may exert pro-oncogenic functions in melanoma and Galc silencing, leading to dec...

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Detalles Bibliográficos
Autores principales: Capoferri, Davide, Chiodelli, Paola, Corli, Marzia, Belleri, Mirella, Scalvini, Elisa, Mignani, Luca, Guerra, Jessica, Grillo, Elisabetta, De Giorgis, Veronica, Manfredi, Marcello, Presta, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342161/
https://www.ncbi.nlm.nih.gov/pubmed/37445731
http://dx.doi.org/10.3390/ijms241310555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342161/
https://www.ncbi.nlm.nih.gov/pubmed/37445731
http://dx.doi.org/10.3390/ijms241310555

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