Succinyl-CoA Synthetase Dysfunction as a Mechanism of Mitochondrial Encephalomyopathy: More than Just an Oxidative Energy Deficit

Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans. SCS catalyzes the interconversion of succinyl-CoA to succinate, coupled to substrate-level phosphorylation of either ADP...

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Detalles Bibliográficos
Autores principales: Lancaster, Makayla S., Graham, Brett H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342173/
https://www.ncbi.nlm.nih.gov/pubmed/37445899
http://dx.doi.org/10.3390/ijms241310725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342173/
https://www.ncbi.nlm.nih.gov/pubmed/37445899
http://dx.doi.org/10.3390/ijms241310725

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