A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype

Fanconi anemia (FA) develops due to a mutation in one of the FANC genes that are involved in the repair of interstrand crosslinks (ICLs). FANCG, a member of the FA core complex, is essential for ICL repair. Previous FANCG-deficient mouse models were generated with drug-based selection cassettes in m...

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Detalles Bibliográficos
Autores principales: Shah, Ronak, van den Berk, Paul C. M., Pritchard, Colin E. J., Song, Ji-Ying, Kreft, Maaike, Pilzecker, Bas, Jacobs, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342586/
https://www.ncbi.nlm.nih.gov/pubmed/37446306
http://dx.doi.org/10.3390/ijms241311129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342586/
https://www.ncbi.nlm.nih.gov/pubmed/37446306
http://dx.doi.org/10.3390/ijms241311129

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