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Interplay between Diffusion and Bond Cleavage Reaction for Determining Release in Polymer–Drug Conjugates
In conjugated polymeric drug delivery systems, both the covalent bond degradation rate and the diffusion of the freely moving drug particles affect the release profile of the formulation. Using Monte Carlo simulations in spherical matrices, the release kinetics resulting from the competition between...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342812/ https://www.ncbi.nlm.nih.gov/pubmed/37444909 http://dx.doi.org/10.3390/ma16134595 |