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The difficulty of aligning intrinsically disordered protein sequences as assessed by conservation and phylogeny
Intrinsically disordered proteins (IDPs) are proteins that lack a stable 3D structure but maintain a biological function. It has been frequently suggested that IDPs are difficult to align because they tend to have fewer conserved residues compared to ordered proteins, but to our knowledge this has n...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343074/ https://www.ncbi.nlm.nih.gov/pubmed/37440576 http://dx.doi.org/10.1371/journal.pone.0288388 |