Structure of puromycin-sensitive aminopeptidase and polyglutamine binding

Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as well as peptides released from the proteasome, including polyglutamine. We report the crystal structure of PSA at 2.3 Ǻ. Overall, the en...

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Detalles Bibliográficos
Autores principales: Madabushi, Sowmya, Chow, K. Martin, Song, Eun Suk, Goswami, Anwesha, Hersh, Louis B., Rodgers, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343166/
https://www.ncbi.nlm.nih.gov/pubmed/37440518
http://dx.doi.org/10.1371/journal.pone.0287086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343166/
https://www.ncbi.nlm.nih.gov/pubmed/37440518
http://dx.doi.org/10.1371/journal.pone.0287086

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