Synthesis and Evaluation of (99m)Tc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography

Prostate-specific membrane antigen (PSMA) is a well-validated prostate cancer marker but reported PSMA-targeted tracers derived from the Lys-urea-Glu pharmacophore including the clinically validated [(99m)Tc]Tc-EDDA/HYNIC-iPSMA have high off-target uptake in kidneys, spleen, and salivary glands. In...

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Detalles Bibliográficos
Autores principales: Lu, Kelly, Zhang, Chengcheng, Zhang, Zhengxing, Kuo, Hsiou-Ting, Colpo, Nadine, Bénard, François, Lin, Kuo-Shyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343272/
https://www.ncbi.nlm.nih.gov/pubmed/37446782
http://dx.doi.org/10.3390/molecules28135120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343272/
https://www.ncbi.nlm.nih.gov/pubmed/37446782
http://dx.doi.org/10.3390/molecules28135120

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