Cargando…

Synthesis and Evaluation of (99m)Tc-Labeled PSMA-Targeted Tracers Based on the Lys-Urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography

Prostate-specific membrane antigen (PSMA) is a well-validated prostate cancer marker but reported PSMA-targeted tracers derived from the Lys-urea-Glu pharmacophore including the clinically validated [(99m)Tc]Tc-EDDA/HYNIC-iPSMA have high off-target uptake in kidneys, spleen, and salivary glands. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Kelly, Zhang, Chengcheng, Zhang, Zhengxing, Kuo, Hsiou-Ting, Colpo, Nadine, Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343272/ https://www.ncbi.nlm.nih.gov/pubmed/37446782 http://dx.doi.org/10.3390/molecules28135120

Ejemplares similares

Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
por: Kuo, Hsiou-Ting, et al.
Publicado: (2023)

What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake
por: Kuo, Hsiou-Ting, et al.
Publicado: (2022)

Monosodium Glutamate Reduces (68)Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model
por: Rousseau, Etienne, et al.
Publicado: (2018)

Synthesis and Preclinical Evaluation of Three Novel (68)Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging
por: Verena, Arsyangela, et al.
Publicado: (2023)

Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of (68)Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics
por: Bendre, Shreya, et al.
Publicado: (2020)

Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple N-Methylations for Melanoma Imaging with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2020)

(68)Ga-Labeled [Thz(14)]Bombesin(7–14) Analogs: Promising GRPR-Targeting Agonist PET Tracers with Low Pancreas Uptake
por: Wang, Lei, et al.
Publicado: (2023)

Synthesis and Evaluation of (68)Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

[(99m)Tc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic
por: Maurin, Michał, et al.
Publicado: (2022)

Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging
por: Bendre, Shreya, et al.
Publicado: (2023)

Design, synthesis and evaluation of (18)F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging
por: Zhang, Zhengxing, et al.
Publicado: (2017)

Preclinical Melanoma Imaging with (68)Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET
por: Zhang, Chengcheng, et al.
Publicado: (2017)

(18)F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography
por: Zhang, Chengcheng, et al.
Publicado: (2019)

Reducing the Kidney Uptake of High Contrast CXCR4 PET Imaging Agents via Linker Modifications
por: Kwon, Daniel, et al.
Publicado: (2022)

(68)Ga-Labeled [Leu(13)ψThz(14)]Bombesin(7–14) Derivatives: Promising GRPR-Targeting PET Tracers with Low Pancreas Uptake
por: Wang, Lei, et al.
Publicado: (2022)

Pharmacokinetics of the phosphatidylserine tracers (99m)Tc-lactadherin and (99m)Tc-annexin V in pigs
por: Poulsen, Runa H, et al.
Publicado: (2013)

Comparing (99m)Tc-PSMA to (99m)Tc-MDP in Prostate Cancer Staging of the Skeletal System
por: Kabunda, Joseph, et al.
Publicado: (2021)

Evaluation of agonist and antagonist radioligands for somatostatin receptor imaging of breast cancer using positron emission tomography
por: Dude, Iulia, et al.
Publicado: (2017)

Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue
por: Lau, Joseph, et al.
Publicado: (2019)

Development of in-House Synthesis and Quality Control of [(99m)Tc]Tc-PSMA-I&S
por: Plhak, Elisabeth, et al.
Publicado: (2023)

Novel (68)Ga-Labeled Pyridine-Based Fibroblast Activation Protein-Targeted Tracers with High Tumor-to-Background Contrast
por: Verena, Arsyangela, et al.
Publicado: (2023)

Optimized (68)Ga-Labeled Urea-Based PSMA-Targeted PET Tracers for Prostate Cancer
por: Wu, Yitian, et al.
Publicado: (2022)

(99m)TcO(4)(-)/(99m)Tc-MIBI dual-tracer scintigraphy for preoperative localization of parathyroid adenomas
por: Huang, Zhongke, et al.
Publicado: (2018)

Automated synthesis and quality control of [(99m)Tc]Tc-PSMA for radioguided surgery (in a [(68)Ga]Ga-PSMA workflow)
por: Aalbersberg, Else A., et al.
Publicado: (2020)

Evaluation of Radiation dosimetry of (99m)Tc-HYNIC-PSMA and imaging in prostate cancer
por: Zhang, Jianping, et al.
Publicado: (2020)

Preparation and Biological Evaluation of [(99m)Tc]Tc-CNGU as a PSMA-Targeted Radiotracer for the Imaging of Prostate Cancer
por: Xiao, Di, et al.
Publicado: (2020)

One-Step (18)F-Labeling and Preclinical Evaluation of Prostate-Specific Membrane Antigen Trifluoroborate Probes for Cancer Imaging
por: Kuo, Hsiou-Ting, et al.
Publicado: (2019)

[(99cm)Tc]Tc-PSMA-I&S-SPECT/CT: experience in prostate cancer imaging in an outpatient center
por: Werner, P., et al.
Publicado: (2020)

Optimization of the Pharmacokinetic Profile of [(99m)Tc]Tc-N(4)-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence
por: Günther, Thomas, et al.
Publicado: (2022)

Eligibility for (177)Lu-PSMA Therapy Depends on the Choice of Companion Diagnostic Tracer: A Comparison of (68)Ga-PSMA-11 and (99m)Tc-MIP-1404 in Metastatic Castration-Resistant Prostate Cancer
por: Cook, Gary J.R., et al.
Publicado: (2023)

A Review on the Current State and Future Perspectives of [(99m)Tc]Tc-Housed PSMA-i in Prostate Cancer
por: Brunello, Sara, et al.
Publicado: (2022)

[(18)F]PSMA-1007 PET is comparable to [(99m)Tc]Tc-DMSA SPECT for renal cortical imaging
por: Valind, Kristian, et al.
Publicado: (2023)

Author Correction: Evaluation of Radiation dosimetry of (99m)Tc-HYNIC-PSMA and imaging in prostate cancer
por: Zhang, Jianping, et al.
Publicado: (2020)

Direct comparison of (99m)Tc-PSMA SPECT/CT and (68)Ga-PSMA PET/CT in patients with prostate cancer
por: Albalooshi, Batool, et al.
Publicado: (2020)

Head-to-head comparison of (99m)Tc-PSMA and (99m)Tc-MDP SPECT/CT in diagnosing prostate cancer bone metastasis: a prospective, comparative imaging trial
por: Zhang, Yu, et al.
Publicado: (2022)

Diffuse hepatic and splenic Tc-99m MDP tracer uptake in case of multiple myeloma
por: Sood, Ashwani, et al.
Publicado: (2010)

Extraosseous accumulation of bone scan tracer (99m)Tc-methylene diphosphonate in a phlebolith
por: Kulkarni, Mukta, et al.
Publicado: (2012)

Initial Experience of Clinical Use of [(99m)Tc]Tc-PSMA-T4 in Patients with Prostate Cancer. A Pilot Study
por: Ćwikła, Jarosław B., et al.
Publicado: (2021)

Optimizing the Profile of [(99m)Tc]Tc–NT(7–13) Tracers in Pancreatic Cancer Models by Means of Protease Inhibitors
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2020)

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [(99m)Tc]Tc-ADAPT6 and [(99m)Tc]Tc-(HE)(3)-G3, for Imaging of HER2-Positive Breast Cancer
por: Bragina, Olga, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kesdelutpt6cidld223tclurka