Scalable Preparation of the Masked Acyl Cyanide TBS-MAC

This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed synthesis that involves: (1) acetylation of malononitrile to form the sodium enolate, (2) protonation of the enola...

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Detalles Bibliográficos
Autores principales: Hinton, Haley, Patterson, Jack, Hume, Jared, Patel, Krunal, Pigza, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343380/
https://www.ncbi.nlm.nih.gov/pubmed/37446749
http://dx.doi.org/10.3390/molecules28135087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343380/
https://www.ncbi.nlm.nih.gov/pubmed/37446749
http://dx.doi.org/10.3390/molecules28135087

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