A Coumarin–Imidazothiadiazole Derivative, SP11 Abrogates Tumor Growth by Targeting HSP90 and Its Client Proteins

Despite several treatment options for blood cancer, mortality remains high due to relapse and the disease’s aggressive nature. Elevated levels of HSP90, a molecular chaperone essential for protein folding, are associated with poor prognosis in leukemia and lymphoma. HSP90 as a target for chemotherap...

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Detalles Bibliográficos
Autores principales: Nirgude, Snehal, Shahana M. V., Ravindran, Febina, Kumar, Sujeet, Sharma, Shivangi, Mahadeva, Raghunandan, Mhatre, Anisha, Karki, Subhas S., Choudhary, Bibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343479/
https://www.ncbi.nlm.nih.gov/pubmed/37446888
http://dx.doi.org/10.3390/molecules28135226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343479/
https://www.ncbi.nlm.nih.gov/pubmed/37446888
http://dx.doi.org/10.3390/molecules28135226

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