A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition

Glioblastoma (GBM) is a deadly brain tumor characterized by signaling dysregulation and aberrant cell cycle control. The CDK4/6-Rb axis is dysregulated in approximately 80% of all GBM cases. In this study, the anti-GBM effect of a novel pyrimidin-2-amine, LH20 was evaluated in vitro using the primar...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Li, Youbin, Liu, Dong, Zheng, Danyang, Li, Xiaogang, Li, Chang, Huang, Caihui, Wang, Yun, Wang, Xuesong, Li, Qifu, Xu, Junyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343613/
https://www.ncbi.nlm.nih.gov/pubmed/37446710
http://dx.doi.org/10.3390/molecules28135047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343613/
https://www.ncbi.nlm.nih.gov/pubmed/37446710
http://dx.doi.org/10.3390/molecules28135047

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