Cargando…

A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition

Glioblastoma (GBM) is a deadly brain tumor characterized by signaling dysregulation and aberrant cell cycle control. The CDK4/6-Rb axis is dysregulated in approximately 80% of all GBM cases. In this study, the anti-GBM effect of a novel pyrimidin-2-amine, LH20 was evaluated in vitro using the primar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yan, Li, Youbin, Liu, Dong, Zheng, Danyang, Li, Xiaogang, Li, Chang, Huang, Caihui, Wang, Yun, Wang, Xuesong, Li, Qifu, Xu, Junyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343613/ https://www.ncbi.nlm.nih.gov/pubmed/37446710 http://dx.doi.org/10.3390/molecules28135047

Ejemplares similares

CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
por: Zhou, Yan, et al.
Publicado: (2021)

The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
por: Zhao, Wenpeng, et al.
Publicado: (2023)

Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells
por: Li, Juntao, et al.
Publicado: (2020)

Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity
por: Huang, Si, et al.
Publicado: (2022)

Mechanisms of Cell Cycle Arrest and Apoptosis in Glioblastoma
por: Gousias, Konstantinos, et al.
Publicado: (2022)

Multiple Beneficial Effects of Aloesone from Aloe vera on LPS-Induced RAW264.7 Cells, Including the Inhibition of Oxidative Stress, Inflammation, M1 Polarization, and Apoptosis
por: Wang, Yan, et al.
Publicado: (2023)

Water-Extracted Ganoderma lucidum Induces Apoptosis and S-Phase Arrest via Cyclin-CDK2 Pathway in Glioblastoma Cells
por: Cheng, An-Yi, et al.
Publicado: (2020)

Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models
por: Wang, Yan, et al.
Publicado: (2022)

Targeting CDK9 for the Treatment of Glioblastoma
por: Ranjan, Alice, et al.
Publicado: (2021)

Haloperidol Induced Cell Cycle Arrest and Apoptosis in Glioblastoma Cells
por: Papadopoulos, Fotios, et al.
Publicado: (2020)

Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme
por: Lubanska, Dorota, et al.
Publicado: (2017)

Design, Synthesis, Antitumour Evaluation, and In Silico Studies of Pyrazolo-[1,5-c]quinazolinone Derivatives Targeting Potential Cyclin-Dependent Kinases
por: Zheng, Danyang, et al.
Publicado: (2023)

Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells
por: Zhang, Lin, et al.
Publicado: (2016)

JSI-124 Induces Cell Cycle Arrest and Regulates the Apoptosis in Glioblastoma Cells
por: Tsai, Tai-Hsin, et al.
Publicado: (2023)

Current Immunotherapies for Glioblastoma Multiforme
por: Huang, Boyuan, et al.
Publicado: (2021)

CDK4/6 inhibition is more active against the glioblastoma proneural subtype
por: Li, Ming, et al.
Publicado: (2017)

Herg K(+) Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells
por: Staudacher, Ingo, et al.
Publicado: (2014)

RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells
por: Tsai, Tai-Hsin, et al.
Publicado: (2023)

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma
por: Kong, Yang, et al.
Publicado: (2019)

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway
por: Xu, Xingxing, et al.
Publicado: (2020)

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
por: Wang, Yahua, et al.
Publicado: (2017)

TARGETING CANCER STEM CELLS WITH A CDK2 INHIBITOR IN GLIOBLASTOMA
por: Mahmnoudian, Elham, et al.
Publicado: (2023)

RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis
por: Yu, Min, et al.
Publicado: (2021)

PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
por: Wang, Ji, et al.
Publicado: (2023)

Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis
por: Tang, Qin, et al.
Publicado: (2019)

B4GalT1 Regulates Apoptosis and Autophagy of Glioblastoma In Vitro and In Vivo
por: Wang, Pu, et al.
Publicado: (2020)

CBMS-3 SEARCH FOR COMPOUNDS WITH ANTI-TUMOUR EFFECTS AGAINST GLIOBLASTOMA
por: Iwashimizu, Sonoka, et al.
Publicado: (2022)

Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells
por: Liu, Feili, et al.
Publicado: (2016)

5-Demethylnobiletin mediates cell cycle arrest and apoptosis via the ERK1/2/AKT/STAT3 signaling pathways in glioblastoma cells
por: Zhang, Xuehua, et al.
Publicado: (2023)

Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives
por: Nyein, Chan Myae, et al.
Publicado: (2018)

Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest
por: Khan, Muhammad, et al.
Publicado: (2012)

Radix Glycyrrhizae Preparata Induces Cell Cycle Arrest and Induced Caspase-Dependent Apoptosis in Glioblastoma Multiforme
por: Lin, Tsung-Ying, et al.
Publicado: (2022)

Combination of RGD Compound and Low-Dose Paclitaxel Induces Apoptosis in Human Glioblastoma Cells
por: Chang, Ming-Wei, et al.
Publicado: (2012)

Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest
por: Vítovcová, Barbora, et al.
Publicado: (2023)

Autophagy suppression potentiates the anti-glioblastoma effect of asparaginase in vitro and in vivo
por: Chen, Qicheng, et al.
Publicado: (2017)

Identification of an Immune-Related Prognostic Risk Model in Glioblastoma
por: Lin, Zhiying, et al.
Publicado: (2022)

Association between SET expression and glioblastoma cell apoptosis and proliferation
por: He, Kunyan, et al.
Publicado: (2016)

Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway
por: Lu, Fengqin, et al.
Publicado: (2020)

Advances in mitophagy and mitochondrial apoptosis pathway-related drugs in glioblastoma treatment
por: Li, Weiping, et al.
Publicado: (2023)

A tree shrew glioblastoma model recapitulates features of human glioblastoma
por: Tong, Yaohui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a6r73oqrpv34f20pq0isem82h3