Three-Step Synthesis of the Antiepileptic Drug Candidate Pynegabine

Pynegabine, an antiepileptic drug candidate in phase I clinical trials, is a structural analog of the marketed drug retigabine with improved chemical stability, strong efficacy, and a better safety margin. The reported shortest synthetic route for pynegabine contains six steps and involves the manip...

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Detalles Bibliográficos
Autores principales: Sun, Yi-Jing, Gong, Ya-Ling, Lu, Shi-Chao, Zhang, Shi-Peng, Xu, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343641/
https://www.ncbi.nlm.nih.gov/pubmed/37446549
http://dx.doi.org/10.3390/molecules28134888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343641/
https://www.ncbi.nlm.nih.gov/pubmed/37446549
http://dx.doi.org/10.3390/molecules28134888

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