Cargando…
Design, Synthesis, Molecular Docking Study and Biological Evaluation of Novel γ-Carboline Derivatives of Latrepirdine (Dimebon) as Potent Anticancer Agents
A series of novel γ-Carboline derivatives were designed and synthesized using the Suzuki coupling reaction to identify the leads for the activity against cancer. Interestingly, these compounds were tested for their anticancer activity against the cell lines, particularly human cancer cell lines MCF7...
Autores principales: | Voggu, Ramakrishna, Karmakar, Arundhati, Puli, Venkat Swamy, Damerla, V. Surendra Babu, Mogili, Padma, Amaladass, P., Chidara, Sridhar, Pasunooti, Kalyan Kumar, Gupta, Sarika |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343707/ https://www.ncbi.nlm.nih.gov/pubmed/37446626 http://dx.doi.org/10.3390/molecules28134965 |
Ejemplares similares
-
Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon(®))
por: Gorin, Boris I., et al.
Publicado: (2023) -
A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice
por: Chaprov, Kirill, et al.
Publicado: (2021) -
Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer’s Disease
por: Eckert, Schamim H, et al.
Publicado: (2018) -
Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo
por: Steele, John W, et al.
Publicado: (2009) -
Dimebon disappointment
por: Jones, Roy W
Publicado: (2010)