Bayesian Optimization-Assisted Screening to Identify Improved Reaction Conditions for Spiro-Dithiolane Synthesis

Bayesian optimization (BO)-assisted screening was applied to identify improved reaction conditions toward a hundred-gram scale-up synthesis of 2,3,7,8-tetrathiaspiro[4.4]nonane (1), a key synthetic intermediate of 2,2-bis(mercaptomethyl)propane-1,3-dithiol [tetramercaptan pentaerythritol]. Starting...

Descripción completa

Detalles Bibliográficos
Autores principales: Kondo, Masaru, Wathsala, Hettiarachchige Dona Piyumi, Ishikawa, Kazunori, Yamashita, Daisuke, Miyazaki, Takeshi, Ohno, Yoji, Sasai, Hiroaki, Washio, Takashi, Takizawa, Shinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343712/
https://www.ncbi.nlm.nih.gov/pubmed/37446842
http://dx.doi.org/10.3390/molecules28135180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343712/
https://www.ncbi.nlm.nih.gov/pubmed/37446842
http://dx.doi.org/10.3390/molecules28135180

Ejemplares similares