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Bayesian Optimization-Assisted Screening to Identify Improved Reaction Conditions for Spiro-Dithiolane Synthesis

Bayesian optimization (BO)-assisted screening was applied to identify improved reaction conditions toward a hundred-gram scale-up synthesis of 2,3,7,8-tetrathiaspiro[4.4]nonane (1), a key synthetic intermediate of 2,2-bis(mercaptomethyl)propane-1,3-dithiol [tetramercaptan pentaerythritol]. Starting...

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Detalles Bibliográficos
Autores principales:	Kondo, Masaru, Wathsala, Hettiarachchige Dona Piyumi, Ishikawa, Kazunori, Yamashita, Daisuke, Miyazaki, Takeshi, Ohno, Yoji, Sasai, Hiroaki, Washio, Takashi, Takizawa, Shinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343712/ https://www.ncbi.nlm.nih.gov/pubmed/37446842 http://dx.doi.org/10.3390/molecules28135180

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