Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells

The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). It has shown positive effects on solid tumours such as melanoma, breast, and colon carcinoma in clinical phase I studies. As the treatment of CLL cells with combinations of fludarabine and metal c...

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Detalles Bibliográficos
Autores principales: Schleser, Sebastian W., Krytovych, Oleksandr, Ziegelmeier, Tim, Groß, Elisabeth, Kasparkova, Jana, Brabec, Viktor, Weber, Thomas, Schobert, Rainer, Mueller, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343763/
https://www.ncbi.nlm.nih.gov/pubmed/37446835
http://dx.doi.org/10.3390/molecules28135173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343763/
https://www.ncbi.nlm.nih.gov/pubmed/37446835
http://dx.doi.org/10.3390/molecules28135173

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