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Palladium and Platinum Complexes of the Antimetabolite Fludarabine with Vastly Enhanced Selectivity for Tumour over Non-Malignant Cells
The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). It has shown positive effects on solid tumours such as melanoma, breast, and colon carcinoma in clinical phase I studies. As the treatment of CLL cells with combinations of fludarabine and metal c...
Autores principales: | Schleser, Sebastian W., Krytovych, Oleksandr, Ziegelmeier, Tim, Groß, Elisabeth, Kasparkova, Jana, Brabec, Viktor, Weber, Thomas, Schobert, Rainer, Mueller, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343763/ https://www.ncbi.nlm.nih.gov/pubmed/37446835 http://dx.doi.org/10.3390/molecules28135173 |
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