Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives

The main aim of the current project was to investigate the effect of the linker size in 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives, known as a group of antiepileptic drug candidates, on their affinity towards voltage-gated sodium channels (VGSCs). The rationale of the study was based both on...

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Detalles Bibliográficos
Autores principales: Paruch, Kinga, Kaproń, Barbara, Łuszczki, Jarogniew J., Paneth, Agata, Plech, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343781/
https://www.ncbi.nlm.nih.gov/pubmed/37446948
http://dx.doi.org/10.3390/molecules28135287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343781/
https://www.ncbi.nlm.nih.gov/pubmed/37446948
http://dx.doi.org/10.3390/molecules28135287

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