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Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model

Objective: Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of pr...

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Autores principales: Zhang, Juwei, Zhou, Jinsong, Huang, Yue, Lin, Zheng, Zhang, Suhong, Qiu, Minglian, Xiang, Zhisheng, Hu, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343810/
https://www.ncbi.nlm.nih.gov/pubmed/37447155
http://dx.doi.org/10.3390/nu15132828
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author Zhang, Juwei
Zhou, Jinsong
Huang, Yue
Lin, Zheng
Zhang, Suhong
Qiu, Minglian
Xiang, Zhisheng
Hu, Zhijian
author_facet Zhang, Juwei
Zhou, Jinsong
Huang, Yue
Lin, Zheng
Zhang, Suhong
Qiu, Minglian
Xiang, Zhisheng
Hu, Zhijian
author_sort Zhang, Juwei
collection PubMed
description Objective: Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of preoperative DAI on health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC). Methods: Data on dietary intakes were collected using a validated food-frequency questionnaire (FFQ). DAI was calculated for all study participants based on FFQ data of each participant. The study involved conducting several follow-up activities with patients diagnosed with ESCC to evaluate their quality of life. The approach employed in the study was to conduct a telephone interview. The EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and the Esophageal Cancer Module (EORTC QLQ-OES18) were used to collect data on the quality of life of the patients; all patients completed the full follow-up. Results: This prospective study was performed on 376 participants who were recruited from Fujian Cancer Hospital and First Hospital of Fujian Medical University. They all were diagnosed with ESCC. The results indicated that the time to deterioration of global health status (p = 0.043), cognitive functioning (p = 0.031), dry mouth (p = 0.019), and speech problems (p = 0.031) significantly delay in the high DAI group. Univariate and multivariate Cox regression analysis showed that global health status (HR = 0.718, 95% CI: 0.532–0.969), cognitive functioning (HR = 0.641, 95% CI: 0.450–0.913), dry mouth (HR = 0.637, 95% CI: 0.445–0.911), and speech problems (HR = 0.651, 95% CI: 0.449–0.945) were improved in the high DAI group. Conclusions: Prognostic value of preoperative DAI was significant for patients with ESCC who undergo surgical intervention. Its level was positively correlated with the postoperative quality of life of patients, which can delay and improve the occurrence of postoperative physical function and symptom deterioration.
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spelling pubmed-103438102023-07-14 Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model Zhang, Juwei Zhou, Jinsong Huang, Yue Lin, Zheng Zhang, Suhong Qiu, Minglian Xiang, Zhisheng Hu, Zhijian Nutrients Article Objective: Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of preoperative DAI on health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC). Methods: Data on dietary intakes were collected using a validated food-frequency questionnaire (FFQ). DAI was calculated for all study participants based on FFQ data of each participant. The study involved conducting several follow-up activities with patients diagnosed with ESCC to evaluate their quality of life. The approach employed in the study was to conduct a telephone interview. The EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and the Esophageal Cancer Module (EORTC QLQ-OES18) were used to collect data on the quality of life of the patients; all patients completed the full follow-up. Results: This prospective study was performed on 376 participants who were recruited from Fujian Cancer Hospital and First Hospital of Fujian Medical University. They all were diagnosed with ESCC. The results indicated that the time to deterioration of global health status (p = 0.043), cognitive functioning (p = 0.031), dry mouth (p = 0.019), and speech problems (p = 0.031) significantly delay in the high DAI group. Univariate and multivariate Cox regression analysis showed that global health status (HR = 0.718, 95% CI: 0.532–0.969), cognitive functioning (HR = 0.641, 95% CI: 0.450–0.913), dry mouth (HR = 0.637, 95% CI: 0.445–0.911), and speech problems (HR = 0.651, 95% CI: 0.449–0.945) were improved in the high DAI group. Conclusions: Prognostic value of preoperative DAI was significant for patients with ESCC who undergo surgical intervention. Its level was positively correlated with the postoperative quality of life of patients, which can delay and improve the occurrence of postoperative physical function and symptom deterioration. MDPI 2023-06-21 /pmc/articles/PMC10343810/ /pubmed/37447155 http://dx.doi.org/10.3390/nu15132828 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Juwei
Zhou, Jinsong
Huang, Yue
Lin, Zheng
Zhang, Suhong
Qiu, Minglian
Xiang, Zhisheng
Hu, Zhijian
Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title_full Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title_fullStr Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title_full_unstemmed Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title_short Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model
title_sort association between the preoperative dietary antioxidant index and postoperative quality of life in patients with esophageal squamous cell carcinoma: a prospective study based on the ttd model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343810/
https://www.ncbi.nlm.nih.gov/pubmed/37447155
http://dx.doi.org/10.3390/nu15132828
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