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Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design
Nanopore sequencers can select which DNA molecules to sequence, rejecting a molecule after analysis of a small initial part. Currently, selection is based on predetermined regions of interest that remain constant throughout an experiment. Sequencing efforts, thus, cannot be re-focused on molecules l...
Autores principales: | Weilguny, Lukas, De Maio, Nicola, Munro, Rory, Manser, Charlotte, Birney, Ewan, Loose, Matthew, Goldman, Nick |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344778/ https://www.ncbi.nlm.nih.gov/pubmed/36593407 http://dx.doi.org/10.1038/s41587-022-01580-z |
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