Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy

Monoclonal antibodies (Abs) that recognize major histocompatability complex (MHC)-presented tumor antigens in a manner similar to T cell receptors (TCRs) have great potential as cancer immunotherapeutics. However, isolation of ‘TCR-mimic’ (TCRm) Abs is laborious because Abs have not evolved the stru...

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Detalles Bibliográficos
Autores principales: Yang, Xinbo, Nishimiya, Daisuke, Löchte, Sara, Jude, Kevin M., Borowska, Marta, Savvides, Christina S., Dougan, Michael, Su, Leon, Zhao, Xiang, Piehler, Jacob, Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344781/
https://www.ncbi.nlm.nih.gov/pubmed/36593402
http://dx.doi.org/10.1038/s41587-022-01567-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344781/
https://www.ncbi.nlm.nih.gov/pubmed/36593402
http://dx.doi.org/10.1038/s41587-022-01567-w

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