Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions

We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyse both protein-protein and protein-DNA interfaces and it is validated on a dataset of clinically relevant mutations. In addition...

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Detalles Bibliográficos
Autores principales: Kugler, Valentina, Lieb, Andreas, Guerin, Nathan, Donald, Bruce R., Stefan, Eduard, Kaserer, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344873/
https://www.ncbi.nlm.nih.gov/pubmed/37443295
http://dx.doi.org/10.1038/s42003-023-05089-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344873/
https://www.ncbi.nlm.nih.gov/pubmed/37443295
http://dx.doi.org/10.1038/s42003-023-05089-2

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