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Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions

We report an Osprey-based computational protocol to prospectively identify oncogenic mutations that act via disruption of molecular interactions. It is applicable to analyse both protein-protein and protein-DNA interfaces and it is validated on a dataset of clinically relevant mutations. In addition...

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Detalles Bibliográficos
Autores principales:	Kugler, Valentina, Lieb, Andreas, Guerin, Nathan, Donald, Bruce R., Stefan, Eduard, Kaserer, Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344873/ https://www.ncbi.nlm.nih.gov/pubmed/37443295 http://dx.doi.org/10.1038/s42003-023-05089-2

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