Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

AIM: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere with the enzyme activity of KDAC8. These compound...

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Detalles Bibliográficos
Autores principales: Schweipert, Markus, Amurthavasan, Anuja, Meyer-Almes, Franz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344891/
https://www.ncbi.nlm.nih.gov/pubmed/37455831
http://dx.doi.org/10.37349/etat.2023.00144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344891/
https://www.ncbi.nlm.nih.gov/pubmed/37455831
http://dx.doi.org/10.37349/etat.2023.00144

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