Cargando…

Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

AIM: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere with the enzyme activity of KDAC8. These compound...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schweipert, Markus, Amurthavasan, Anuja, Meyer-Almes, Franz-Josef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Open Exploration Publishing 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344891/ https://www.ncbi.nlm.nih.gov/pubmed/37455831 http://dx.doi.org/10.37349/etat.2023.00144

Ejemplares similares

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch
por: Jänsch, Niklas, et al.
Publicado: (2018)

Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4
por: Schweipert, Markus, et al.
Publicado: (2021)

Methionine 274 Is Not the Determining Factor for Selective Inhibition of Histone Deacetylase 8 (HDAC8) by L-Shaped Inhibitors
por: Jänsch, Niklas, et al.
Publicado: (2022)

Significance of Five-Membered Heterocycles in Human Histone Deacetylase Inhibitors
por: Frühauf, Anton, et al.
Publicado: (2023)

Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases
por: Frühauf, Anton, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4(3H)-One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity
por: Khetmalis, Yogesh Mahadu, et al.
Publicado: (2023)

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors
por: Baud, Matthias G J, et al.
Publicado: (2013)

Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids
por: Jakubkiene, Virginija, et al.
Publicado: (2022)

Interpreting clinical assays for histone deacetylase inhibitors
por: Martinet, Nadine, et al.
Publicado: (2011)

High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays
por: Moreno-Yruela, Carlos, et al.
Publicado: (2021)

High throughput screening identifies modulators of histone deacetylase inhibitors
por: Gaupel, Ann-Christin, et al.
Publicado: (2014)

Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
por: Yelton, Caleb J., et al.
Publicado: (2018)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
por: Yan, Wensheng, et al.
Publicado: (2012)

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
por: Minisini, Martina, et al.
Publicado: (2022)

Repurposing approved drugs as potential inhibitors of 3CL-protease of SARS-CoV-2: Virtual screening and structure based drug design
por: Meyer-Almes, Franz-Josef
Publicado: (2020)

PROTAC chemical probes for histone deacetylase enzymes
por: Patel, Urvashi, et al.
Publicado: (2023)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Butyrate Histone Deacetylase Inhibitors
por: Steliou, Kosta, et al.
Publicado: (2012)

3‐Chloro‐5‐Substituted‐1,2,4‐Thiadiazoles (TDZs) as Selective and Efficient Protein Thiol Modifiers
por: Jänsch, Niklas, et al.
Publicado: (2022)

A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma
por: Zhang, Shanshan, et al.
Publicado: (2019)

Analysis of the interactome of Schistosoma mansoni histone deacetylase 8
por: Caby, Stéphanie, et al.
Publicado: (2017)

Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
por: Lapierre, Marion, et al.
Publicado: (2016)

Harnessing the HDAC–histone deacetylase enzymes, inhibitors and how these can be utilised in tissue engineering
por: Lawlor, Liam, et al.
Publicado: (2019)

Histone deacetylase inhibitors in multiple myeloma
por: Deleu, Sarah, et al.
Publicado: (2009)

Histone deacetylase inhibitors in Hodgkin lymphoma
por: Buglio, Daniela, et al.
Publicado: (2010)

Clinical Toxicities of Histone Deacetylase Inhibitors
por: Subramanian, Srividya, et al.
Publicado: (2010)

Acetylation and Histone Deacetylase Inhibitors in Cancer
por: Kortenhorst, Madeleine S. Q., et al.
Publicado: (2006)

Histone Deacetylase Inhibitors as Anticancer Drugs
por: Eckschlager, Tomas, et al.
Publicado: (2017)

The application of histone deacetylases inhibitors in glioblastoma
por: Chen, Rui, et al.
Publicado: (2020)

Histone Deacetylases and Their Inhibitors in Cancer Epigenetics
por: Hassell, Kelly N.
Publicado: (2019)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Histone Deacetylase Enzymes as Potential Drug Targets in Cancer and Parasitic Diseases
por: Ouaissi, Mehdi, et al.
Publicado: (2006)

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8
por: Olson, David E., et al.
Publicado: (2014)

Histone‐deacetylase 8 drives the immune response and the growth of glioma
por: Mormino, Alessandro, et al.
Publicado: (2021)

Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis
por: Zheng, Hanxi, et al.
Publicado: (2023)

Interferon Regulatory Factor-8 Is Important for Histone Deacetylase Inhibitor-Mediated Antitumor Activity
por: Banik, Debarati, et al.
Publicado: (2012)

Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer
por: Alzoubi, Samer, et al.
Publicado: (2016)

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells
por: Mattioli, Elisabetta, et al.
Publicado: (2019)

Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro
por: Freese, Kim, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3jqsbs9embekq8mm896qqehdlq