Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an in...

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Detalles Bibliográficos
Autores principales: Goretzki, Benedikt, Wiedemann, Christoph, McCray, Brett A., Schäfer, Stefan L., Jansen, Jasmin, Tebbe, Frederike, Mitrovic, Sarah-Ana, Nöth, Julia, Cabezudo, Ainara Claveras, Donohue, Jack K., Jeffries, Cy M., Steinchen, Wieland, Stengel, Florian, Sumner, Charlotte J., Hummer, Gerhard, Hellmich, Ute A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344929/
https://www.ncbi.nlm.nih.gov/pubmed/37443299
http://dx.doi.org/10.1038/s41467-023-39808-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344929/
https://www.ncbi.nlm.nih.gov/pubmed/37443299
http://dx.doi.org/10.1038/s41467-023-39808-4

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