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Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an in...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344929/ https://www.ncbi.nlm.nih.gov/pubmed/37443299 http://dx.doi.org/10.1038/s41467-023-39808-4 |