Mitochondrial folate metabolism–mediated α-linolenic acid exhaustion masks liver fibrosis resolution

Sustainable TGF-β1 signaling drives organ fibrogenesis. However, the cellular adaptation to maintain TGF-β1 signaling remains unclear. In this study, we revealed that dietary folate restriction promoted the resolution of liver fibrosis in mice with nonalcoholic steatohepatitis. In activated hepatic...

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Detalles Bibliográficos
Autores principales: Gao, Yanjie, Zheng, Bingfeng, Xu, Shuaiqi, Zhao, Zhibo, Liu, Wanyue, Wang, Tingyu, Yuan, Manman, Sun, Xueqing, Tan, Yang, Xu, Qiang, Wu, Xingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344950/
https://www.ncbi.nlm.nih.gov/pubmed/37307917
http://dx.doi.org/10.1016/j.jbc.2023.104909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344950/
https://www.ncbi.nlm.nih.gov/pubmed/37307917
http://dx.doi.org/10.1016/j.jbc.2023.104909

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