Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

The aim of this study was to examine, in biochemical detail, the functional role of the Arg152 residue in the selenoprotein Glutathione Peroxidase 4 (GPX4), whose mutation to His is involved in Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD). Wild-type and mutated recombinant enzymes with sele...

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Detalles Bibliográficos
Autores principales: Roveri, Antonella, Di Giacinto, Flavio, Rossetto, Monica, Cozza, Giorgio, Cheng, Qing, Miotto, Giovanni, Zennaro, Lucio, Di Paolo, Maria Luisa, Arnér, Elias S.J., De Spirito, Marco, Maiorino, Matilde, Ursini, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345155/
https://www.ncbi.nlm.nih.gov/pubmed/37413766
http://dx.doi.org/10.1016/j.redox.2023.102806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345155/
https://www.ncbi.nlm.nih.gov/pubmed/37413766
http://dx.doi.org/10.1016/j.redox.2023.102806

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