Exon-intron boundary inhibits m(6)A deposition, enabling m(6)A distribution hallmark, longer mRNA half-life and flexible protein coding

Regional bias of N(6)-methyladenosine (m(6)A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m(6)A deposition. By deep learning modeling, we find that exon-intron boundary represses a proportion (12% to 34%) of m(6)A deposition a...

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Detalles Bibliográficos
Autores principales: Luo, Zhiyuan, Ma, Qilian, Sun, Shan, Li, Ningning, Wang, Hongfeng, Ying, Zheng, Ke, Shengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345190/
https://www.ncbi.nlm.nih.gov/pubmed/37443320
http://dx.doi.org/10.1038/s41467-023-39897-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345190/
https://www.ncbi.nlm.nih.gov/pubmed/37443320
http://dx.doi.org/10.1038/s41467-023-39897-1

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