Cargando…

Exon-intron boundary inhibits m(6)A deposition, enabling m(6)A distribution hallmark, longer mRNA half-life and flexible protein coding

Regional bias of N(6)-methyladenosine (m(6)A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m(6)A deposition. By deep learning modeling, we find that exon-intron boundary represses a proportion (12% to 34%) of m(6)A deposition a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Zhiyuan, Ma, Qilian, Sun, Shan, Li, Ningning, Wang, Hongfeng, Ying, Zheng, Ke, Shengdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345190/ https://www.ncbi.nlm.nih.gov/pubmed/37443320 http://dx.doi.org/10.1038/s41467-023-39897-1

Ejemplares similares

Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
por: Ke, Shengdong, et al.
Publicado: (2010)

Deep learning modeling m(6)A deposition reveals the importance of downstream cis-element sequences
por: Luo, Zhiyuan, et al.
Publicado: (2022)

Pre-mRNA processing includes N(6) methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”
por: Darnell, Robert B., et al.
Publicado: (2018)

m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
por: Ke, Shengdong, et al.
Publicado: (2017)

Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma
por: Sivasudhan, Enakshi, et al.
Publicado: (2021)

mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster
por: Lepennetier, Gildas, et al.
Publicado: (2016)

The Exon Junction Complex and intron removal prevent re-splicing of mRNA
por: Joseph, Brian, et al.
Publicado: (2021)

Exon junction complex shapes the m(6)A epitranscriptome
por: Yang, Xin, et al.
Publicado: (2022)

A majority of m(6)A residues are in the last exons, allowing the potential for 3′ UTR regulation
por: Ke, Shengdong, et al.
Publicado: (2015)

Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS
por: Taylor, Richard, et al.
Publicado: (2022)

Functional Characterization of Two Variants at the Intron 6—Exon 7 Boundary of the KCNQ2 Potassium Channel Gene Causing Distinct Epileptic Phenotypes
por: Mosca, Ilaria, et al.
Publicado: (2022)

Viral and Cellular N(6)-Methyladenosine (m(6)A) and N(6), 2′-O-Dimethyladenosine (m(6)Am) Epitranscriptomes in KSHV Life Cycle
por: Tan, Brandon, et al.
Publicado: (2017)

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
por: Khare, Tarang, et al.
Publicado: (2012)

Intron exon boundary junctions in human genome have in-built unique structural and energetic signals
por: Mishra, Akhilesh, et al.
Publicado: (2021)

SR proteins regulate V(6) exon splicing of CD44 pre-mRNA
por: Loh, Tiing Jen, et al.
Publicado: (2016)

A single m(6)A modification in U6 snRNA diversifies exon sequence at the 5’ splice site
por: Ishigami, Yuma, et al.
Publicado: (2021)

Aberrant RNA m(6)A modification in gastrointestinal malignancies: versatile regulators of cancer hallmarks and novel therapeutic opportunities
por: Shen, Li-Ting, et al.
Publicado: (2023)

Transcriptome-Wide Detection of Intron/Exon Definition in the Endogenous Pre-mRNA Transcripts of Mammalian Cells and Its Regulation by Depolarization
por: Liu, Ling, et al.
Publicado: (2022)

Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members
por: Wang, Huiwen, et al.
Publicado: (2010)

Alternative splicing of a cryptic exon embedded in intron 6 of SMN1 and SMN2
por: Yoshimoto, Satomi, et al.
Publicado: (2016)

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer
por: Huang, Zhiqing, et al.
Publicado: (2006)

Compound Heterozygous Missense and Deep Intronic Variants in NDUFAF6 Unraveled by Exome Sequencing and mRNA Analysis
por: Catania, Alessia, et al.
Publicado: (2018)

The Emerging Role of m6A Modification in Endocrine Cancer
por: Ji, Xiaoyu, et al.
Publicado: (2023)

M6ADD: a comprehensive database of m(6)A modifications in diseases
por: Zhou, Dianshuang, et al.
Publicado: (2021)

The Role of m(6)A Modification and m(6)A Regulators in Esophageal Cancer
por: Li, Yuekao, et al.
Publicado: (2022)

Relationship between mRNA stability and intron presence
por: Wang, Hai-Fang, et al.
Publicado: (2007)

mRNA splicing is modulated by intronic microRNAs
por: Farberov, Luba, et al.
Publicado: (2023)

Olivetti M6 640
Publicado: (1993)

Secondary Structure of a Conserved Domain in an Intron of Influenza A M1 mRNA
por: Jiang, Tian, et al.
Publicado: (2014)

The m(6)A‑methylase complex and mRNA export()
por: Lesbirel, Simon, et al.
Publicado: (2019)

Chlorpromazine affects autophagy in association with altered Rag GTPase–mTORC1–TFEB signaling
por: Li, Ningning, et al.
Publicado: (2023)

Profiling of RNA N(6)-Methyladenosine Methylation Reveals the Critical Role of m(6)A in Chicken Adipose Deposition
por: Cheng, Bohan, et al.
Publicado: (2021)

Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome
por: Linder, Bastian, et al.
Publicado: (2015)

m6AVar: a database of functional variants involved in m(6)A modification
por: Zheng, Yueyuan, et al.
Publicado: (2018)

m6ASNP: a tool for annotating genetic variants by m(6)A function
por: Jiang, Shuai, et al.
Publicado: (2018)

m6Acorr: an online tool for the correction and comparison of m(6)A methylation profiles
por: Li, Jianwei, et al.
Publicado: (2020)

m(6)Am-seq reveals the dynamic m(6)Am methylation in the human transcriptome
por: Sun, Hanxiao, et al.
Publicado: (2021)

A comprehensive review of m(6)A/m(6)Am RNA methyltransferase structures
por: Oerum, Stephanie, et al.
Publicado: (2021)

M6AREG: m(6)A-centered regulation of disease development and drug response
por: Liu, Shuiping, et al.
Publicado: (2022)

The role of m(6)A and m(6)Am RNA modifications in the pathogenesis of diabetes mellitus
por: Benak, Daniel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aljd9a85v9k4br8depnue8lklu