Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma

A challenge when targeting T-cell lymphoma with chimeric antigen receptor (CAR) T-cell therapy is that target antigens are often shared between T cells and tumor cells, resulting in fratricide between CAR T cells and on-target cytotoxicity on normal T cells. CC chemokine receptor 4 (CCR4) is highly...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Keisuke, Gomez, Angela M., Kuramitsu, Shunichiro, Siurala, Mikko, Da, Tong, Agarwal, Sangya, Song, Decheng, Scholler, John, Rotolo, Antonia, Posey, Avery D., Rook, Alain H., Haun, Paul L., Ruella, Marco, Young, Regina M., June, Carl H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345856/
https://www.ncbi.nlm.nih.gov/pubmed/37058474
http://dx.doi.org/10.1182/bloodadvances.2022008327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345856/
https://www.ncbi.nlm.nih.gov/pubmed/37058474
http://dx.doi.org/10.1182/bloodadvances.2022008327

Ejemplares similares