ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 antagonist and ClpP agonist that has shown preclini...

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Detalles Bibliográficos
Autores principales: Jackson, Evangeline R., Duchatel, Ryan J., Staudt, Dilana E., Persson, Mika L., Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, W. Samantha N., Grand, Marion Le, Kearney, Padraic S., Douglas, Alicia M., Findlay, Izac J., Germon, Zacary P., McEwen, Holly P., Beitaki, Tyrone S., Patabendige, Adjanie, Skerrett-Byrne, David A., Nixon, Brett, Smith, Nathan D., Day, Bryan, Manoharan, Neevika, Nagabushan, Sumanth, Hansford, Jordan R., Govender, Dinisha, McCowage, Geoff B., Firestein, Ron, Howlett, Meegan, Endersby, Raelene, Gottardo, Nicholas G., Alvaro, Frank, Waszak, Sebastian M., Larsen, Martin R., Colino-Sanguino, Yolanda, Valdes-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, André, Nicolas, Hulleman, Esther, Eisenstat, David D., Vitanza, Nicholas A., Nazarian, Javad, Koschmann, Carl, Mueller, Sabine, Cain, Jason E., Dun, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345962/
http://dx.doi.org/10.1158/0008-5472.CAN-23-0186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345962/
http://dx.doi.org/10.1158/0008-5472.CAN-23-0186

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