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HLA‐DR3 mediated CD4 T cell response against GAD65 in type 1 diabetes patients

AIM: We planned this study to identify diabetogenic glutamic acid decarboxylase (GAD65) peptides possibly responsible for human leucocyte antigen (HLA)‐DR3/DQ2‐mediated activation of GAD65‐specific CD4 T cells in type 1 diabetes (T1D). METHODS: Top 30 GAD65 peptides, found to strongly bind in silico...

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Detalles Bibliográficos
Autores principales: Chuzho, Neihenuo, Mishra, Neetu, Tandon, Nikhil, Kanga, Uma, Mishra, Gunja, Sharma, Akanksha, Mehra, Narinder K., Kumar, Neeraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345980/
https://www.ncbi.nlm.nih.gov/pubmed/37309552
http://dx.doi.org/10.1111/1753-0407.13406